KaKs_Calculator Calculate selective pressure on coding sequences


KaKs_Calculator adopts model selection and model averaging to calculate nonsynonymous (Ka) and synonymous (Ks) substitution rates, attempting to include as many features as needed for accurately capturing evolutionary information in protein-coding sequences. In addition, several existing methods for calculating Ka and Ks are also incorporated into KaKs_Calculator.


  1. KaKs_Calculator: Calculating Ka and Ks Through Model Selection And Model Averaging.
    Cite this
    Zhang Z, Li J, Zhao XQ, Wang J, Wong GK, Yu J, 2006 Nov - Genomics, Proteomics & Bioinformatics
    Cited by 708 (Google Schoolar as of August 3, 2021)
  2. KaKs_Calculator 2.0: A Toolkit Incorporating Gamma-Series Methods and Sliding Window Strategies
    Dapeng Wang, Yubin Zhang, Zhang Zhang, Jiang Zhu, Jun Yu, 2010/5/6 - Genomics, Proteomics & Bioinformatics
    Cited by 519 (Google Schoolar as of August 3, 2021)


  1. Zhang Zhang zhangzhang@big.ac.cn

    National Genomics Data Center, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, China

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zha***g@big.ac.cn (June 28, 2017)
dot***g@gmail.com (June 29, 2017)
wan***n@big.ac.cn (January 17, 2018)
Tool TypeApplication
CategoryNatural selection, Comparative analysis
PlatformsLinux/Unix, MAC OS X, Windows
User InterfaceDesktop GUI, Terminal Command Line
Latest Release1.2 (June 24, 2017)
Download Count2631
Submitted ByZhang Zhang