KaKs_Calculator calculate nonsynonymous & synonymous substitution rates


KaKs_Calculator adopts model selection and model averaging to calculate nonsynonymous (Ka) and synonymous (Ks) substitution rates, attempting to include as many features as needed for accurately capturing evolutionary information in protein-coding sequences. In addition, several existing methods for calculating Ka and Ks are also incorporated into KaKs_Calculator.


  1. KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging
    Cite this
    Zhang Zhang, Jun Li, Xiao-Qian Zhao, Jun Wang, Gane Ka-Shu Wong, Jun Yu, 2007/5/25 - Genomics, Proteomics & Bioinformatics
    Cited by 392 (Google Schoolar as of January 5, 2018)
  2. KaKs_Calculator 2.0: A Toolkit Incorporating Gamma-Series Methods and Sliding Window Strategies
    Dapeng Wang, Yubin Zhang, Zhang Zhang, Jiang Zhu, Jun Yu, 2010/5/6 - Genomics, Proteomics & Bioinformatics
    Cited by 125 (Google Schoolar as of January 5, 2018)


  1. Zhang Zhang zhangzhang@big.ac.cn

    BIG Data Center, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, China

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zha***g@big.ac.cn (June 28, 2017)
dot***g@gmail.com (June 29, 2017)
wan***n@big.ac.cn (January 17, 2018)
Tool TypeApplication
CategoryNatural selection, Comparative analysis
PlatformsLinux/Unix, MAC OS X, Windows
User InterfaceDesktop GUI, Terminal Command Line
Latest Release1.2 (June 24, 2017)
Download Count1888
Submitted ByZhang Zhang