PSiTE a phylogeny guided simulator for tumor evolution

PSiTE is a phylogeny guided simulator for tumor evolution. It first simulates somatic variants (Single Nucleotide Variants (SNVs) and Copy Number Variants (CNVs)) along the history of tumor evolution and then generates Next Generation Sequencing (NGS) data for tumor samples. PSiTE can simulate a wide range of tumor data including single sector, multi-sectoring bulk tumor as well single cell data. It provides a powerful approach simulating tumor evolution with different demographic histories and allows efficient benchmarking of methods for clonality analysis.