| 项目编号 |
PRJCA001131 |
| 项目标题 |
Genomes reveal hard and soft selective sweep of kiang and donkey for adaptation |
| 涉及领域 |
Evolution |
| 数据类型 |
Whole genome sequencing
Genome sequencing and assembly
|
| 物种名称 |
Equus asinus asinus
Equus kiang
|
| 描述信息 |
Here, we firstly assembled a de novo genome of Kiang, and re-sequenced genomes of another 5 kiangs. Genetic innovations including structural variation and rapidly evolved genes were recapitulated in kiang. Particularly, the rapid evolution of immune genes might be related to the evolution of immune system, and hard selective sweep of EPAS1 gene is likely coupled to high altitude adaptation. However, we didn't find the frequent occurrence of hard selective sweep in Kiang. To investigate relationship between kiang and domestic donkey, we further re-sequenced the whole genomes from 93 domestic donkeys across the world. In contrast to previous viewpoint, rare genetic introgression was found between Kiang and domestic donkey, indicating minor genetic contribution of kiang to domestic donkey. We found common occurrence of soft selective sweep and revealed rapid evolution of HIF-pathway for high altitude adaptation of Tibetan domestic donkey. |
| 样品范围 |
Multispecies |
| 发布日期 |
2020-01-01 |
| 出版信息 |
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDB13020600
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31321002
|
|
|
|
| 提交者 |
Dong-Dong
Wu (wudongdong@mail.kiz.ac.cn)
|
| 提交单位 |
Kunming Institute of Zoology, Chinese Academy of Sciences |
| 提交日期 |
2018-11-20 |
