| Accession |
PRJCA001131 |
| Title |
Genomes reveal hard and soft selective sweep of kiang and donkey for adaptation |
| Relevance |
Evolution |
| Data types |
Whole genome sequencing
Genome sequencing and assembly
|
| Organisms |
Equus asinus asinus
Equus kiang
|
| Description |
Here, we firstly assembled a de novo genome of Kiang, and re-sequenced genomes of another 5 kiangs. Genetic innovations including structural variation and rapidly evolved genes were recapitulated in kiang. Particularly, the rapid evolution of immune genes might be related to the evolution of immune system, and hard selective sweep of EPAS1 gene is likely coupled to high altitude adaptation. However, we didn't find the frequent occurrence of hard selective sweep in Kiang. To investigate relationship between kiang and domestic donkey, we further re-sequenced the whole genomes from 93 domestic donkeys across the world. In contrast to previous viewpoint, rare genetic introgression was found between Kiang and domestic donkey, indicating minor genetic contribution of kiang to domestic donkey. We found common occurrence of soft selective sweep and revealed rapid evolution of HIF-pathway for high altitude adaptation of Tibetan domestic donkey. |
| Sample scope |
Multispecies |
| Release date |
2020-01-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 33293529
|
Donkey genomes provide new insights into domestication and selection for coat color
|
Nature Communications
|
10.1038/s41467-020-19813-7
|
2020
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDB13020600
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31321002
|
|
|
|
| Submitter |
Dong-Dong
Wu (wudongdong@mail.kiz.ac.cn)
|
| Organization |
Kunming Institute of Zoology, Chinese Academy of Sciences |
| Submission date |
2018-11-20 |
