项目编号 PRJCA002164
项目标题 Global Immune Characterization of Hepatocellular Carcinoma Identifies Macrophage and T cell Subsets Associated with Disease Progression
涉及领域 Medical
数据类型 Transcriptome or Gene expression
物种名称 Homo sapiens
描述信息 Diverse immune cells in the tumor microenvironment form a complex ecosystem, but our knowledge of their heterogeneity and dynamics within hepatocellular carcinoma (HCC) remains poorly understood. We assess the variability and phenotypes of immune cells within HCC microenvironment by performing single-cell RNA sequencing on 41,698 immune cells from 7 pairs of HCC tumors and nontumor liver tissues.
样品范围 Single cell
发布日期 2020-01-25
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
33298893 Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression Cell Discovery 10.1038/s41421-020-00214-5 2020
35577269 Single-Cell Transcriptomics of Liver Cancer: Hype or Insights? Cellular and Molecular Gastroenterology and Hepatology 10.1016/j.jcmgh.2022.04.014 2022
37063858 Three-dimensional and single-cell sequencing of liver cancer reveals comprehensive host-virus interactions in HBV infection Frontiers in Immunology 10.3389/fimmu.2023.1161522 2023
39850878 Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC Frontiers in Immunology 10.3389/fimmu.2024.1487372 2025
39239526 DAB2 + macrophages support FAP + fibroblasts in shaping tumor barrier and inducing poor clinical outcomes in liver cancer Theranostics 10.7150/thno.99046 2024
40581358 SeuratIntegrate: an R package to facilitate the use of integration methods with Seurat Bioinformatics 10.1093/bioinformatics/btaf358 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 91859105
National Natural Science Foundation of China (NSFC) 81961128025
Basic Research Project from Technology Commission of Shanghai Municipality 17JC1402200
提交者 song guo he (docsong2013@163.com)
提交单位 Fudan University
提交日期 2020-01-25

项目包含数据信息

资源名称 描述
BioSample (14)  show -
GSA (1) -
CRA002308 Global Immune Characterization of Hepatocellular Carcinoma Identifies Macrophage and T cell Subsets Associated with Disease Progression