| 项目编号 | PRJCA002335 | ||||||||||
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| 项目标题 | TLK2 Drives Chromatin Dynamics | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 |
Epigenomics
Transcriptome or Gene expression |
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| 物种名称 | Homo sapiens | ||||||||||
| 描述信息 | The chromatin dynamics and mechanisms in Cancer stem cell (CSC) reprogramming are not characterized. Here by mapping binding of CTCF and Cohesin, we found that CTCF-cohesin hubs are changed in CSCs. We further uncovered TLK2 involved in CTCF-cohesin hubs reconstruction. The functional assay demonstrated that depletion of TLK2 strictly inhibit the formation of cancer stem cells and reduced the chemotherapy and immunotherapy tolerance. | ||||||||||
| 样品范围 | Monoisolate | ||||||||||
| 发布日期 | 2025-06-30 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Zifeng Wang (wangzf@sysucc.org.cn) | ||||||||||
| 提交单位 | Sun Yat-sen University | ||||||||||
| 提交日期 | 2020-03-05 |