| 项目编号 | PRJCA002771 | ||||||||
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| 项目标题 | Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution | ||||||||
| 涉及领域 | Medical | ||||||||
| 数据类型 |
Whole genome sequencing
Raw sequence reads |
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| 物种名称 | Homo sapiens | ||||||||
| 描述信息 | Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic and epigenetic information through generations. The transcriptional landscapes of human FGC development have been revealed; however, the epigenetic reprogramming process of FGCs remains elusive. Here, we profiled the genome-wide DNA methylation and chromatin accessibility of human FGCs at different phases as well as gonadal niche cells at single-cell resolution. Our single-cell epigenomic atlas as well as functional assay provide valuable insights for understanding the strongly heterogeneous, unsynchronized, yet highly robust nature of human germline cell development. | ||||||||
| 样品范围 | Single cell | ||||||||
| 发布日期 | 2022-01-02 | ||||||||
| 项目资金来源 |
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| 提交者 | Fuchou Tang (tangfuchou@pku.edu.cn) | ||||||||
| 提交单位 | Peking University | ||||||||
| 提交日期 | 2020-05-31 |
| 资源名称 | 描述 |
|---|---|
| BioSample (825) show | - |