| HRA000186
(Controlled Access)
|
Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic and epigenetic information through generations. The transcriptional landscapes of human FGC development have been revealed; however, the epigenetic reprogramming process of FGCs remains elusive. Here, we profiled the genome-wide DNA methylation and chromatin accessibility of human FGCs at different phases as well as gonadal niche cells at single-cell resolution. Our single-cell epigenomic atlas as well as functional assay provide valuable insights for understanding the strongly heterogeneous, unsynchronized, yet highly robust nature of human germline cell development. |
