| Accession |
PRJCA004411 |
| Title |
T cell Tolerance Induction of HSCT |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
Epigenomics
|
| Organisms |
Homo sapiens
|
| Description |
Achieving T cell tolerance ensures superior clinical outcomes in hematopoietic stem cell transplantation (HSCT). However, the in vivo T cell tolerance profiles in physiological state need to be further delineated. Here, we characterized the gene expression profile in tolerant T cells which was induced in healthy donors by granulocyte colony-stimulating factor, a stem cell mobilizer extensively used in HSCT. We identified suppressor of cytokine signaling 1 (SOCS1) as an essential immune checkpoint for T cell tolerance in the mouse models and primary T cells in the HSCT context. Further spatial multiomics analysis characterized the distinct three-dimensional genome architecture and the gene regulatory network in tolerant T cells. We found STAT3 competes with CTCF and mediates the formation of a new chromatin loop between the SOCS1 promoter and upstream super enhancers during the induction of T cell tolerance. This study identifies SOCS1 as a key immune checkpoint and potential immune target for improving outcome of patients with HSCT. |
| Sample scope |
Multiisolate |
| Release date |
2021-02-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 35585676
|
Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft-Versus-Host Disease
|
Advanced Science
|
10.1002/advs.202200978
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Key Research and Development Program of China
|
|
2017YFA0104500
|
|
|
|
| Submitter |
cheng
li (cheng_li@pku.edu.cn)
|
| Organization |
Peking University |
| Submission date |
2021-02-01 |
