项目编号 PRJCA004844
项目标题 Single-Cell Profiling of Heterogeneous Chronic Rhinosinusitis Subtypes
涉及领域 Medical
数据类型 Transcriptome or Gene expression
物种名称 Homo sapiens
描述信息 We performed single-cell RNA-sequencing to portrait the cellular landscape, including immune cells, epithelial cells, and stromal cells of nasal mucosa from health and three CRS subtypes (CRSsNP, neCRSwNP and eCRSwNP)
样品范围 Single cell
发布日期 2022-08-03
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
36138182 Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis Nature Immunology 10.1038/s41590-022-01312-0 2022
38444858 Increased glycolysis and cellular crosstalk in eosinophilic chronic rhinosinusitis with nasal polyps Frontiers in Immunology 10.3389/fimmu.2024.1321560 2024
39614076 Granzyme K+ CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps Nature Communications 10.1038/s41467-024-54685-1 2024
40753172 TLR4+ group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases Nature Communications 10.1038/s41467-025-62532-0 2025
39644500 M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps Clinical and Translational Allergy 10.1002/clt2.70014 2024
39438439 IL-1β-induced epithelial cell and fibroblast transdifferentiation promotes neutrophil recruitment in chronic rhinosinusitis with nasal polyps Nature Communications 10.1038/s41467-024-53307-0 2024
40993240 A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues Nature Immunology 10.1038/s41590-025-02267-8 2025
39361432 Neutrophils in nasal polyps exhibit transcriptional adaptation and proinflammatory roles that depend on local polyp milieu JCI Insight 10.1172/jci.insight.184739 2024
40195539 SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps Experimental & Molecular Medicine 10.1038/s12276-025-01440-1 2025
40689541 Epithelial Lining Fluid Cystatin SN is a Noninvasive Biomarker for Predicting Type 2 Chronic Rhinosinusitis Allergy 10.1111/all.16652 2025
40744699 Phenotypic Analysis of Nasal CD69 + CD4 + Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps Journal of Rhinology 10.18787/jr.2025.00025 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
No funding support
提交者 Wei Lv (lili20020615@sina.com)
提交单位 Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
提交日期 2021-04-08

项目包含数据信息

资源名称 描述
BioSample (21)  show -