| Accession |
PRJCA005497 |
| Title |
Single-cell transcriptome sequencing of Kawasaki disease |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Kawasaki disease (KD) is the most common cause of acquired heart disease in children in developed countries. Based on single-cell RNA sequencing (scRNA-seq), we profiled peripheral blood mononuclear cells (PBMCs) from patients with acute KD before and after intravenous immunoglobulin (IVIG) therapy and from healthy controls. We identified the dynamics of cell abundance, gene expression patterns and biological processes underlying the immune dysregulation of each cell compartment. The single-cell landscape of both innate and adaptive immune responses provides new insights into pathogenesis and therapy of KD. |
| Sample scope |
Single cell |
| Release date |
2021-06-16 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2016YFC0901700
|
|
|
|
| Submitter |
Zhen
Wang (zwang01@sibs.ac.cn)
|
| Organization |
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences |
| Submission date |
2021-06-16 |
