Accession SAMC1786653
Accession in Other Database GSA-Human: HRS208540
Sample name P5_before
Title Pre-treatment P5
Sample type Human sample
Organism Homo sapiens
Description PBMCs from KD patient P5 before IVIG therapy
Attributes *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA000973 in the GSA-Human system.
Release date 2021-06-25
BioProject Accession PRJCA005497
Submitter Zhen  Wang  (zwang01@sibs.ac.cn)
Organization Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Submission date 2023-06-18

Sample Data

Resource name Description
GSA-Human (1) -
HRA000973  (Controlled Access) Kawasaki disease (KD) is the most common cause of acquired heart disease in children in developed countries. Based on single-cell RNA sequencing (scRNA-seq), we profiled peripheral blood mononuclear cells (PBMCs) from patients with acute KD before and after intravenous immunoglobulin (IVIG) therapy and from healthy controls. We identified the dynamics of cell abundance, gene expression patterns and biological processes underlying the immune dysregulation of each cell compartment. The single-cell landscape of both innate and adaptive immune responses provides new insights into pathogenesis and therapy of KD.
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