项目编号 PRJCA005565
项目标题 Single-cell transcriptomic profiling of human colorectal cancer reveals a direct interaction between tumor-specific FAP+ fibroblasts and MARCO+ macrophages
涉及领域 Medical
数据类型 Raw sequence reads
物种名称 Homo sapiens
描述信息 Colorectal cancer (CRC) is one of the most common maliganancies. Understanding the tumor microenvironment will benefit the clinical therapy for CRC. Here we used scRNA-seq data from 5 patients, and unraveling a potential interacting cell subsets named MARCO+ macrophages and FAP+ fibroblasts, which may contribute to the formation of a desmoplastic tumor microenvironment and interfere with tumor immunotherapy. We further used spatial transcriptomic analysis to further confirm the potential interaction of these two subsets. Our work highlights the potential therapeutic strategy by disrupting the interaction between these two cell types.
样品范围 Single cell
发布日期 2022-02-09
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
35365629 Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer Nature Communications 10.1038/s41467-022-29366-6 2022
Predicting Gene Spatial Expression and Cancer Prognosis: An Integrated Graph and Image Deep Learning Approach Based on HE Slides BioRxiv 10.1101/2023.07.20.549824 2023
Deciphering metabolic reprogramming of immune cells within the tumor microenvironment Journal of Translational Medicine 10.1186/s12967-025-07069-y 2025
40461882 Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells Nature Cell Biology 10.1038/s41556-025-01673-2 2025
40858107 An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment Cell Reports. Medicine 10.1016/j.xcrm.2025.102310 2025
40659611 KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers Cell Death & Disease 10.1038/s41419-025-07818-3 2025
38903527 A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment Frontiers in Immunology 10.3389/fimmu.2024.1372432 2024
36313703 Spatial transcriptomics technology in cancer research Frontiers in Oncology 10.3389/fonc.2022.1019111 2022
40725477 Construction of Gene Regulatory Networks Based on Spatial Multi-Omics Data and Application in Tumor-Boundary Analysis Genes 10.3390/genes16070821 2025
39872476 Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study The Innovation 10.1016/j.xinn.2024.100745 2025
38697103 Harnessing TME depicted by histological images to improve cancer prognosis through a deep learning system Cell Reports Medicine 10.1016/j.xcrm.2024.101536 2024
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 82073145
National Natural Science Foundation of China (NSFC) 31930035
National Natural Science Foundation of China (NSFC) 91942311
National Natural Science Foundation of China (NSFC) 81971487
Shanghai Science and Technology Commission 20JC1410100
Shanghai Pujiang Program 20PJ1412800
National Natural Science Foundation of China (NSFC) 20ZR1472900
提交者 Youqiong Ye (youqiong.ye@shsmu.edu.cn)
提交单位 Shanghai Jiao Tong University School of Medicie
提交日期 2021-06-22

项目包含数据信息

资源名称 描述
BioSample (12)  show -