| HRA000979
(Controlled Access)
|
Colorectal cancer (CRC) is one of the most common maliganancies. Understanding the tumor microenvironment will benefit the clinical therapy for CRC. Here we used scRNA-seq data from 5 patients, and unraveling a potential interacting cell subsets named MARCO+ macrophages and FAP+ fibroblasts, which may contribute to the formation of a desmoplastic tumor microenvironment and interfere with tumor immunotherapy. We further used spatial transcriptomic analysis to further confirm the potential interaction of these two subsets. Our work highlights the potential therapeutic strategy by disrupting the interaction between these two cell types. |
