Accession

PRJCA005740

Title

Tumor microenvironment remodeling after neoadjuvant immunotherapy in lung cancer

Relevance

Medical

Data types

Transcriptome or Gene expression
Raw sequence reads

Organisms

Homo sapiens

Description

Most patients are still refractory to immunotherapy or acquire resistance. To address the potential therapy-resistant mechanisms and underly the changes of tumor microenvironment (TME) after immunotherapy, we performed scRNA-seq and bulk RNA-seq from the patients with resectable non-small cell lung cancer (NSCLC) before and after PD-1 blockade combined with chemotherapy. We found that the combined therapy significantly remodeled the immune cell compartments in the TME. Patients with different pathologic responses had distinct characteristics of malignant cells and immune cell compositions. Our study provided several potential biomarkers for future immunotherapy and novel strategies to improve response.

Sample scope

Single cell

Release date

2023-01-28

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		81972172

Submitter

Peng Zhang (zhangpeng1121@tongji.edu.cn)

Organization

Shanghai Pulmonary Hospital Tongji University

Submission date

2021-07-06

Project Data

Resource name	Description
BioSample (39) show	-
SAMC1840029	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1840025	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1840021	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1840017	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1840013	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1840009	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1840005	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1840001	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839997	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839994	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839991	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839986	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839982	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839978	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839975	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839971	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839967	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839964	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839960	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839957	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839953	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839950	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839947	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839944	RNA-seq of NSCLC before ICB + chemotherapy
SAMC1839940	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839936	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839932	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839928	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839924	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839920	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839917	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839913	scRNA-seq of NSCLC before ICB + chemotherapy
SAMC1839911	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839906	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839902	scRNA-seq of NSCLC before ICB + chemotherapy
SAMC1839898	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839894	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839889	scRNA-seq of NSCLC after ICB + chemotherapy
SAMC1839885	scRNA-seq of NSCLC before ICB + chemotherapy