| Accession | SAMC1839885 |
|---|---|
| Accession in Other Database | GSA-Human: HRS261231 |
| Sample name | BD-immune-1 |
| Title | scRNA-seq of NSCLC before ICB + chemotherapy |
| Sample type | Human sample |
| Organism | Homo sapiens |
| Description | BD Biosciences single-cell RNA sequencing of NSCLC before neoadjuvant immunotherapy |
| Attributes | *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA001033 in the GSA-Human system. |
| Release date | 2023-01-28 |
| BioProject Accession | PRJCA005740 |
| Submitter | Junjie Hu (zhangpeng1121@tongji.edu.cn) |
| Organization | Shanghai Pulmonary Hospital |
| Submission date | 2023-06-18 |
| Resource name | Description |
|---|---|
| GSA-Human (1) | - |
| HRA001033 (Controlled Access) | Most patients are still refractory to immunotherapy or acquire resistance. We characterized the single-cell transcriptomes of ~92000 cells from 15 non-small cell lung cancer (NSCLC) before and after neoadjuvant PD-1 blockade combined with chemotherapy to decode immunotherapy resistance mechanisms. In addition, we also performed bulk RNA-seq from another 24 patients before therapy as a validation cohort. Our study offers invaluable resources for uncovering immunotherapy resistance. |