| Accession |
PRJCA005787 |
| Title |
Single-cell analysis reveals cellular heterogeneity and novel therapeutic targets in relapsed/refractory AML |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Chemoresistance and relapse are the leading cause of poor outcomes for patients with acute myeloid leukemia (AML). The high intratumoral heterogeneity (ITH) and the co-evolution between leukemia cells and the microenvironment are the main reasons for drug resistance. Utilizing single-cell RNA sequencing (scRNA-seq), we dissect the cellular states and the immune microenvironment of bone marrow from primary refractory or short-term relapsed AML patients. |
| Sample scope |
Single cell |
| Release date |
2022-10-25 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36543880
|
Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia
|
Leukemia
|
10.1038/s41375-022-01789-6
|
2022
|
| 38807380
|
Identification of cell surface markers for acute myeloid leukemia prognosis based on multi-model analysis
|
Journal of Biomedical Research
|
10.7555/JBR.38.20240065
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
32000497
|
|
|
|
| Submitter |
Wang
Qianghu (wangqh@njmu.edu.cn)
|
| Organization |
Nanjing Medical University |
| Submission date |
2021-07-08 |
