| 项目编号 |
PRJCA005787 |
| 项目标题 |
Single-cell analysis reveals cellular heterogeneity and novel therapeutic targets in relapsed/refractory AML |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Chemoresistance and relapse are the leading cause of poor outcomes for patients with acute myeloid leukemia (AML). The high intratumoral heterogeneity (ITH) and the co-evolution between leukemia cells and the microenvironment are the main reasons for drug resistance. Utilizing single-cell RNA sequencing (scRNA-seq), we dissect the cellular states and the immune microenvironment of bone marrow from primary refractory or short-term relapsed AML patients. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-10-25 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36543880
|
Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia
|
Leukemia
|
10.1038/s41375-022-01789-6
|
2022
|
| 38807380
|
Identification of cell surface markers for acute myeloid leukemia prognosis based on multi-model analysis
|
Journal of Biomedical Research
|
10.7555/JBR.38.20240065
|
2024
|
| 41318446
|
Single-cell transcriptome analysis defines novel molecular subtypes and reveals therapeutic implications of T/myeloid mixed-phenotype acute leukemia
|
Genome Medicine
|
10.1186/s13073-025-01585-8
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
32000497
|
|
|
|
| 提交者 |
Wang
Qianghu (wangqh@njmu.edu.cn)
|
| 提交单位 |
Nanjing Medical University |
| 提交日期 |
2021-07-08 |
