| 项目编号 |
PRJCA007781 |
| 项目标题 |
Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN-null glioblastoma |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Genomic alteration can reshape tumor microenvironment (TME) to drive tumor malignancy. However, it remains unclear how PTEN-deficiency influences microenvironment-mediated cell-cell interactions in glioblastoma (GBM). Here, we show that PTEN-deficiency induces a symbiotic glioma-M2 macrophage interaction to support glioma progression. ScRNA-seq data analysis reveals Gal-9/Tim-3 mediated interactions between glioma cells and macrophages. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2021-12-31 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35857445
|
Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN -null glioblastoma
|
Science Advances
|
10.1126/sciadv.abl5165
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81872059
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82072761
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
11871070
|
|
|
|
| 提交者 |
Xiangrong
Ni (nixr@sysucc.org.cn)
|
| 提交单位 |
Sun Yat-sen University Cancer Center |
| 提交日期 |
2021-12-31 |
