样本编号	SAMC1995971
外部数据库编号	GSA-Human: HRS324422
样品名称	540437
样本标题	glioblastoma tissue M48 (PTEN WT)
样品类型	Human sample
物种名称	Homo sapiens
描述信息	glioblastoma tissue M48 (PTEN WT)
样本属性	*由于样本关联的数据集HRA001769尚未在科技部完成人类遗传资源信息备案，本页面只展示部分样本信息。
发布日期	2022-01-06
项目编号	PRJCA007781
提交者	XiangRong Ni (chenzp57@mail.sysu.edu.cn)
提交单位	Sun Yat-sen University
提交日期	2023-06-18

样本包含数据信息

资源名称	描述
GSA-Human (1)	-
HRA001769 (Open Access)	Genomic alteration can reshape tumor microenvironment (TME) to drive tumor malignancy. However, it remains unclear how PTEN-deficiency influences microenvironment-mediated cell-cell interactions in glioblastoma (GBM). Here, we show that PTEN-deficiency induces a symbiotic glioma-M2 macrophage interaction to support glioma progression. ScRNA-seq data analysis reveals Gal-9/Tim-3 mediated interactions between glioma cells and macrophages.

资源名称

描述

GSA-Human (1)

HRA001769 (Open Access)

Genomic alteration can reshape tumor microenvironment (TME) to drive tumor malignancy. However, it remains unclear how PTEN-deficiency influences microenvironment-mediated cell-cell interactions in glioblastoma (GBM). Here, we show that PTEN-deficiency induces a symbiotic glioma-M2 macrophage interaction to support glioma progression. ScRNA-seq data analysis reveals Gal-9/Tim-3 mediated interactions between glioma cells and macrophages.