项目编号 | PRJCA008579 | ||||||||||||||||||||||||||||
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项目标题 | Diploid Genome Architecture Reveals Allelic Bias of the Hybrid Pig | ||||||||||||||||||||||||||||
涉及领域 | Agricultural | ||||||||||||||||||||||||||||
数据类型 |
Whole genome sequencing
Epigenomics Transcriptome or Gene expression in situ Hi-C |
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物种名称 | Sus scrofa | ||||||||||||||||||||||||||||
描述信息 | To understand the allele-specific characteristics of pig genomes regarding to 3D chromatin architecture as well as transcriptional regulation, we introduced a reciprocal cross system of the Berkshire pig (originated from Europe) and Tibetan pig (originated from China), and reconstructed the haplotype-resolved 3D structures of 14 diploid pig genomes using ultra-deep in situ high-throughput chromatin conformation capture (Hi-C) sequencing. We reported the general principles of 3D nucleus organization at diploid scale, and systematically depicted the tissue-, parent-of-origin- and breed- dependent differences in multiscale 3D chromatin structures, including compartments, topologically associating domains (TADs) and promoter-enhancer interactions (PEIs) between the two haploids in the hybrid pigs. | ||||||||||||||||||||||||||||
样品范围 | Multiisolate | ||||||||||||||||||||||||||||
发布日期 | 2023-08-05 | ||||||||||||||||||||||||||||
出版信息 |
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项目资金来源 |
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提交者 | Long Jin (longjin@sicau.edu.cn) | ||||||||||||||||||||||||||||
提交单位 | Sichuan Agricultural University | ||||||||||||||||||||||||||||
提交日期 | 2022-03-08 |