项目编号 PRJCA008579
项目标题 Diploid Genome Architecture Reveals Allelic Bias of the Hybrid Pig
涉及领域 Agricultural
数据类型 Whole genome sequencing
Epigenomics
Transcriptome or Gene expression
in situ Hi-C
物种名称 Sus scrofa
描述信息 To understand the allele-specific characteristics of pig genomes regarding to 3D chromatin architecture as well as transcriptional regulation, we introduced a reciprocal cross system of the Berkshire pig (originated from Europe) and Tibetan pig (originated from China), and reconstructed the haplotype-resolved 3D structures of 14 diploid pig genomes using ultra-deep in situ high-throughput chromatin conformation capture (Hi-C) sequencing. We reported the general principles of 3D nucleus organization at diploid scale, and systematically depicted the tissue-, parent-of-origin- and breed- dependent differences in multiscale 3D chromatin structures, including compartments, topologically associating domains (TADs) and promoter-enhancer interactions (PEIs) between the two haploids in the hybrid pigs.
样品范围 Multiisolate
发布日期 2023-08-05
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
38479837 Haplotype-resolved 3D chromatin architecture of the hybrid pig Genome Research 10.1101/gr.278101.123 2024
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Key R & D Program of China 2020YFA0509500
National Key R & D Program of China 2021YFD1300800
National Natural Science Foundation of China (NSFC) U19A2036
National Natural Science Foundation of China (NSFC) 32102507
National Natural Science Foundation of China (NSFC) 31872335
National Natural Science Foundation of China (NSFC) 32102512
提交者 Long  Jin (longjin@sicau.edu.cn)
提交单位 Sichuan Agricultural University
提交日期 2022-03-08

项目包含数据信息

资源名称 描述
BioSample (30)  show -
GSA (1) -
CRA006472 Diploid Genome Architecture Reveals Allelic Bias of the Hybrid Pig