| Accession | PRJCA008579 | ||||||||||||||||||||||||||||
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| Title | Diploid Genome Architecture Reveals Allelic Bias of the Hybrid Pig | ||||||||||||||||||||||||||||
| Relevance | Agricultural | ||||||||||||||||||||||||||||
| Data types |
Whole genome sequencing
Epigenomics Transcriptome or Gene expression in situ Hi-C |
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| Organisms | Sus scrofa | ||||||||||||||||||||||||||||
| Description | To understand the allele-specific characteristics of pig genomes regarding to 3D chromatin architecture as well as transcriptional regulation, we introduced a reciprocal cross system of the Berkshire pig (originated from Europe) and Tibetan pig (originated from China), and reconstructed the haplotype-resolved 3D structures of 14 diploid pig genomes using ultra-deep in situ high-throughput chromatin conformation capture (Hi-C) sequencing. We reported the general principles of 3D nucleus organization at diploid scale, and systematically depicted the tissue-, parent-of-origin- and breed- dependent differences in multiscale 3D chromatin structures, including compartments, topologically associating domains (TADs) and promoter-enhancer interactions (PEIs) between the two haploids in the hybrid pigs. | ||||||||||||||||||||||||||||
| Sample scope | Multiisolate | ||||||||||||||||||||||||||||
| Release date | 2023-08-05 | ||||||||||||||||||||||||||||
| Publication |
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| Grants |
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| Submitter | Long Jin (longjin@sicau.edu.cn) | ||||||||||||||||||||||||||||
| Organization | Sichuan Agricultural University | ||||||||||||||||||||||||||||
| Submission date | 2022-03-08 |