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Accession PRJCA008874
Title Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
Relevance Medical
Data types Metagenome
Raw sequence reads
Genome sequencing
Organisms Severe acute respiratory syndrome coronavirus 2
Description Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. We did next-generation sequencing of samples from bronchoalveolar lavage fluid and cultured isolates from nine inpatients, eight of whom had visited the Huanan seafood market in Wuhan. Complete and partial 2019-nCoV genome sequences were obtained from these individuals. Viral contigs were connected using Sanger sequencing to obtain the full-length genomes, with the terminal regions determined by rapid amplification of cDNA ends. Phylogenetic analysis of these 2019-nCoV genomes and those of other coronaviruses was used to determine the evolutionary history of the virus and help infer its likely origin. Homology modelling was done to explore the likely receptor-binding properties of the virus.
Sample scope Multispecies
Release date 2022-03-29
Publication
PubMed ID Article title Journal name DOI Year
32007145
Grants
Agency program Grant ID Grant title
National Key Research and Development Programme of China 2016YFD0500301
National Key Research and Development Programme of China 2020YFC0840900
National Key Research and Development Programme of China 2020YFC0840800
National Major Project for Control and Prevention of Infectious Disease in China 2018ZX10732-401
National Major Project for Control and Prevention of Infectious Disease in China 2018ZX10101004
National Major Project for Control and Prevention of Infectious Disease in China 2018ZX10101002
National Major Project for Control and Prevention of Infectious Disease in China 2017ZX10104001
State Key Research Development Program of China 2019YFC1200501
Strategic Priority Research Programme of the Chinese Academy of Sciences XDB29010102
Academic Promotion Programme of Shandong First Medical University 2019QL006
Academic Promotion Programme of Shandong First Medical University 2019PT008
Taishan Scholars Programme of Shandong Province ts201511056
Submitter Changcheng Wu (wucc@ivdc.chinacdc.cn)
Organization China CDC
Submission date 2022-03-29

Project Data

Resource name Description
BioSample (9)  show -
GSA (1) -
CRA006587 Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding