| 项目编号 |
PRJCA010340 |
| 项目标题 |
Immune properties of patients with acute HBV infection |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
To characterize the immune properties of patients with acute HBV infection, we performed scRNA-seq to study the transcriptomic profiles of peripheral blood mononuclear cells (PBMCs) from 4 acute hepatitis B (AHB) patients and 3 healthy donors (HDs) as controls. Single-cell TCR and BCR sequencing was also performed for each subject. One patient had matched liver puncture biopsy specimen, in which the immune cells were isolated and analyzed in parallel . A total of 34, 720 high-quality single cells were ultimately obtained, with an average of 1,340 genes per cell. We obtained 37 cell clusters, each with its unique signature genes and covering diverse cell types and states in the peripheral blood and/or liver tissue |
| 样品范围 |
Single cell |
| 发布日期 |
2024-07-01 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40382385
|
Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice
|
Nature Communications
|
10.1038/s41467-025-59985-8
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
81722029
|
|
|
|
| 提交者 |
Jianhua
Li (jianhuali@fudan.edu.cn)
|
| 提交单位 |
Fudan University |
| 提交日期 |
2022-07-01 |
