| Accession |
PRJCA010556 |
| Title |
Single-cell sequencing dissecting dynamic heterogeneity of ascites ecosystem and therapy-induced evolution during gastric cancer peritoneal metastasis |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Gastric cancer peritoneal metastasis (GCPM) has poor prognosis and high mortality with poor therapeutic outcomes. Study of GPCM is complicated since the complexity of the peritoneal ecosystem and the mechanisms of GCPM remain to be deciphered. We characterized single-cell transcriptomes of 191,987 ascites cancer/immune cells from 35 patients with/without GCPM. Our large-scale single-cell data comprehensively delineates the landscape, dynamic changes, and therapy-induced evolution of immune cells and tumor cells in the peritoneal cavity during GCPM, which may provide a new direction for future research on the molecular mechanisms of GCPM and help design effective treatment strategies for GCPM in the future. |
| Sample scope |
Single cell |
| Release date |
2022-12-12 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36788228
|
Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis
|
Nature Communications
|
10.1038/s41467-023-36310-9
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82072724
|
|
| Department of Education of Liaoning Province
|
|
QNZR2020004
|
|
| Department of Education of Liaoning Province
|
|
2021-YQ-07
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81961128026
|
|
| National Natural Science Foundation of China (NSFC)
|
|
U1908207
|
|
| Major Scientific and Technological Special Project of Liaoning Province of China
|
|
2019020176-JH1/103
|
|
| Overseas training project of Liaoning general higher education
|
|
2019GJWYB022
|
|
|
|
| Submitter |
Zhenning
Wang (josieon826@sina.cn)
|
| Organization |
The First Hospital of China Medical University |
| Submission date |
2022-07-15 |
