| 项目编号 |
PRJCA010556 |
| 项目标题 |
Single-cell sequencing dissecting dynamic heterogeneity of ascites ecosystem and therapy-induced evolution during gastric cancer peritoneal metastasis |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Gastric cancer peritoneal metastasis (GCPM) has poor prognosis and high mortality with poor therapeutic outcomes. Study of GPCM is complicated since the complexity of the peritoneal ecosystem and the mechanisms of GCPM remain to be deciphered. We characterized single-cell transcriptomes of 191,987 ascites cancer/immune cells from 35 patients with/without GCPM. Our large-scale single-cell data comprehensively delineates the landscape, dynamic changes, and therapy-induced evolution of immune cells and tumor cells in the peritoneal cavity during GCPM, which may provide a new direction for future research on the molecular mechanisms of GCPM and help design effective treatment strategies for GCPM in the future. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-12-12 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36788228
|
Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis
|
Nature Communications
|
10.1038/s41467-023-36310-9
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82072724
|
|
| Department of Education of Liaoning Province
|
|
QNZR2020004
|
|
| Department of Education of Liaoning Province
|
|
2021-YQ-07
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81961128026
|
|
| National Natural Science Foundation of China (NSFC)
|
|
U1908207
|
|
| Major Scientific and Technological Special Project of Liaoning Province of China
|
|
2019020176-JH1/103
|
|
| Overseas training project of Liaoning general higher education
|
|
2019GJWYB022
|
|
|
|
| 提交者 |
Zhenning
Wang (josieon826@sina.cn)
|
| 提交单位 |
The First Hospital of China Medical University |
| 提交日期 |
2022-07-15 |
