| 项目编号 |
PRJCA011180 |
| 项目标题 |
Proteogenomic Characterization of MiT Family Translocation Renal Cell Carcinoma |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Comprehensive proteogenomic analysis of microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) tumors and normal adjacent tissues is performed to elucidate the molecular landscape of this disease. Defective DNA repair plays an important role in tRCC carcinogenesis and progression. Metabolic processes are markedly dysregulated at both the mRNA and protein levels. Proteomic and phosphoproteome data identify the mTOR signaling pathway as a potential therapeutic target. Moreover, molecular subtyping and immune infiltration analysis characterize the inter-tumoral heterogeneity of tRCC. Multi-omic integration revealed the dysregulation of cellular processes affected by genomic alterations, including oxidative phosphorylation, autophagy, transcription factor activity, and proteasome function. This study represents a comprehensive proteogenomic analysis of tRCC, providing valuable insights into its biological mechanisms, disease diagnosis, and prognostication. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2022-10-14 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36470859
|
Proteogenomic characterization of MiT family translocation renal cell carcinoma
|
Nature Communications
|
10.1038/s41467-022-34460-w
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
2019YFA0801900
|
|
|
|
| 本项目在其他数据库系统中的项目序列号 |
| 项目序列号 |
数据库名称 |
| OEP002630
|
NGDC-NODE
|
|
|
| 提交者 |
Chen
Ding (chend@fudan.edu.cn)
|
| 提交单位 |
Fudan University |
| 提交日期 |
2022-08-13 |
