| HRA002855
(Controlled Access)
|
Comprehensive proteogenomic analysis of microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) tumors and normal adjacent tissues is performed to elucidate the molecular landscape of this disease. Defective DNA repair plays an important role in tRCC carcinogenesis and progression. Metabolic processes are markedly dysregulated at both the mRNA and protein levels. Proteomic and phosphoproteome data identify the mTOR signaling pathway as a potential therapeutic target. Moreover, molecular subtyping and immune infiltration analysis characterize the inter-tumoral heterogeneity of tRCC. Multi-omic integration revealed the dysregulation of cellular processes affected by genomic alterations, including oxidative phosphorylation, autophagy, transcription factor activity, and proteasome function. This study represents a comprehensive proteogenomic analysis of tRCC, providing valuable insights into its biological mechanisms, disease diagnosis, and prognostication. |
