| Accession |
PRJCA013875 |
| Title |
Genomic and Transcriptomic Landscape of Breast Cancer with Neoadjuvant Chemotherapy |
| Relevance |
Medical |
| Data types |
Exome
Transcriptome or Gene expression
Raw sequence reads
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
We performed whole-exome and RNA sequencing (RNAseq) analysis on 233 clinical samples (including matched pre- and posttreatment tumors) from 50 BC patients with rigorously definite response to NAC. This study revealed an improved understanding of genomic and transcriptomic landscape related to NAC in BC, identified novel biomarkers underlying NAC resistance and provided therapeutics opportunity beyond current neoadjuvant regimens. |
| Sample scope |
Multiisolate |
| Release date |
2023-12-30 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38217005
|
Genomic and transcriptomic analysis of breast cancer identifies novel signatures associated with response to neoadjuvant chemotherapy
|
Genome Medicine
|
10.1186/s13073-024-01286-8
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Department of Science & Technology of Shandong Province
|
Major Science and Technology Innovation Project of Shandong Province
|
2017CXGC1212
|
Screening and validation of breast cancer therapeutic targets through high-throughput omics data
|
|
|
| Submitter |
Zhigang
Yu (yzg@medmail.com.cn)
|
| Organization |
The Second Hospital of Shandong University |
| Submission date |
2022-12-13 |
