| 项目编号 |
PRJCA013875 |
| 项目标题 |
Genomic and Transcriptomic Landscape of Breast Cancer with Neoadjuvant Chemotherapy |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
Transcriptome or Gene expression
Raw sequence reads
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
We performed whole-exome and RNA sequencing (RNAseq) analysis on 233 clinical samples (including matched pre- and posttreatment tumors) from 50 BC patients with rigorously definite response to NAC. This study revealed an improved understanding of genomic and transcriptomic landscape related to NAC in BC, identified novel biomarkers underlying NAC resistance and provided therapeutics opportunity beyond current neoadjuvant regimens. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-12-30 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38217005
|
Genomic and transcriptomic analysis of breast cancer identifies novel signatures associated with response to neoadjuvant chemotherapy
|
Genome Medicine
|
10.1186/s13073-024-01286-8
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Department of Science & Technology of Shandong Province
|
Major Science and Technology Innovation Project of Shandong Province
|
2017CXGC1212
|
Screening and validation of breast cancer therapeutic targets through high-throughput omics data
|
|
|
| 提交者 |
Zhigang
Yu (yzg@medmail.com.cn)
|
| 提交单位 |
The Second Hospital of Shandong University |
| 提交日期 |
2022-12-13 |
