项目编号 PRJCA018245
项目标题 Analysis of metabolic characteristics and metabolic fragility in acute lymphoblastic leukemia
涉及领域 Medical
数据类型 Transcriptome or Gene expression
metabolome
物种名称 Homo sapiens
描述信息 Metabolic reprogramming is a hallmark and therapeutic target in cancer, as cancer cells accumulate metabolic changes to meet biosynthetic and energy demands, sustaining rapid proliferation while generating metabolic heterogeneity. Heterogeneous metabolic preferences and dependencies exist among different cancer types and even within cancer cells of the same tissue. Cancer cells acquire metabolic adaptability by responding to various endogenous and exogenous signals, some of which promote malignant cell growth and render them vulnerable to inhibition by key pathway inhibitors. To explore the metabolic features of acute B-cell lymphoblastic leukemia (B-ALL), we collected bone marrow samples from newly diagnosed patients in the PDT-ALL-2016 cohort at Southern Hospital from 2016-2020 for transcriptome sequencing (n=91) and untargeted metabolomics profiling (n=69), in addition to conducting transcriptome sequencing on two B-ALL cell lines (BALL-1 and HAL-01).
样品范围 Multiisolate
发布日期 2023-07-11
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 82170163
National Natural Science Foundation of China (NSFC) 81970147
National Natural Science Foundation of China (NSFC) 81770170
Science and Technology Planning Project of Guangdong Province 2017A030313601
Clinical Trial Funding of Southern Medical University 2016A020215112
Nanfang Hospital LC2016ZD009/2019CR012
提交者 Hongsheng  Zhou (zhs1@i.smu.edu.cn)
提交单位 Nanfang Hospital, Southern Medical University
提交日期 2023-07-10

项目包含数据信息

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BioSample (93)  show -