Accession

PRJCA018245

Title

Analysis of metabolic characteristics and metabolic fragility in acute lymphoblastic leukemia

Relevance

Medical

Data types

Transcriptome or Gene expression
metabolome

Organisms

Homo sapiens

Description

Metabolic reprogramming is a hallmark and therapeutic target in cancer, as cancer cells accumulate metabolic changes to meet biosynthetic and energy demands, sustaining rapid proliferation while generating metabolic heterogeneity. Heterogeneous metabolic preferences and dependencies exist among different cancer types and even within cancer cells of the same tissue. Cancer cells acquire metabolic adaptability by responding to various endogenous and exogenous signals, some of which promote malignant cell growth and render them vulnerable to inhibition by key pathway inhibitors. To explore the metabolic features of acute B-cell lymphoblastic leukemia (B-ALL), we collected bone marrow samples from newly diagnosed patients in the PDT-ALL-2016 cohort at Southern Hospital from 2016-2020 for transcriptome sequencing (n=91) and untargeted metabolomics profiling (n=69), in addition to conducting transcriptome sequencing on two B-ALL cell lines (BALL-1 and HAL-01).

Sample scope

Multiisolate

Release date

2023-07-11

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		82170163
National Natural Science Foundation of China (NSFC)		81970147
National Natural Science Foundation of China (NSFC)		81770170
Science and Technology Planning Project of Guangdong Province		2017A030313601
Clinical Trial Funding of Southern Medical University		2016A020215112
Nanfang Hospital		LC2016ZD009/2019CR012

Submitter

Hongsheng Zhou (zhs1@i.smu.edu.cn)

Organization

Nanfang Hospital, Southern Medical University

Submission date

2023-07-10

Project Data

Resource name	Description
BioSample (93) show	-
SAMC2926412	Human Acute Lymphoblastic Leukemia Cell Line
SAMC2926411	Mycoplasma Test of BALL-1 Cell Line
SAMC2926336	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926335	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926334	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926333	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926332	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926331	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926330	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926329	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926328	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926327	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926326	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926325	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926324	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926323	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926322	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926321	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926320	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926319	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926318	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926317	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926316	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926315	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926314	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926313	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926312	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926311	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926310	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926309	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926308	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926307	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926306	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926305	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926304	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926303	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926302	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926301	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926300	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926299	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926298	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926297	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926296	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926295	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926294	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926293	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926292	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926291	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926290	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926289	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926288	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926287	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926286	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926285	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926284	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926283	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926282	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926281	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926280	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926279	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926278	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926277	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926276	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926275	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926274	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926273	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926272	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926271	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926270	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926269	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926268	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926267	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926266	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926265	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926264	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926263	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926262	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926261	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926260	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926259	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926258	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926257	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926256	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926255	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926254	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926253	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926252	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926251	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926250	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926249	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926248	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926247	Transcriptomic sequencing of newly diagnosed B-ALL patients
SAMC2926246	Transcriptomic sequencing of newly diagnosed B-ALL patients