| 项目编号 |
PRJCA018695 |
| 项目标题 |
Tumor vasculature at single-cell resolution |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Tumor growth cannot flourish without the oxygen and nutrients supplied by the blood, making angiogenesis induction one of the most critical cancer hallmarks. In this study, we generated a pan-tumor vasculature atlas by integrating in-house and public single-cell datasets. At the single-cell resolution, we dissected ~200,000 vascular cells, including vascular endothelial cells (ECs), lymphatic ECs (LECs), and mural cells (MCs). Our findings contributed to understanding the tumor angiogenesis processes, LEC lineages, MC phenotypes, and intercellular interactions associated with the tumor vascular microenvironment (TVM). Our comprehensive TVM compilations complemented a missing piece of jigsaw puzzle for the single-cell pan-tumor atlas and provided a reference perspective on tumor vascular normalization and anti-angiogenic therapy. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-02-05 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40543508
|
Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma
|
Cell Reports Medicine
|
10.1016/j.xcrm.2025.102200
|
2025
|
| 41636115
|
Integrative single‐cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers
|
Clinical and Translational Medicine
|
10.1002/ctm2.70611
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
2022YFC3601800
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82073020
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32200523
|
|
| Chongqing Natural Science Foundation
|
|
CSTB2023NSCQ-MSX0658
|
|
| Hunan Natural Science Foundation for Distinguished Young Scholars
|
|
2021JJ10073
|
|
| Fundamental Research Funds for the Central Universities
|
|
2023CDJYGRH-YB05
|
|
|
|
| 提交者 |
Mingzhu
Yin (yinmingzhu2008@126.com)
|
| 提交单位 |
Chongqing University |
| 提交日期 |
2023-07-30 |
