Accession | SAMC3758723 |
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Accession in Other Database | GSA-Human: HRS1251423 |
Sample name | HSCR-01-0081-00 |
Title | HSCR-01-0081-00 |
Sample type | Human sample |
Organism | Homo sapiens |
Description | Tumor; Adjacent nonTumor(sample_name:Species-CancerType-DonorID-SampleType; Species(HSCR:Human Single cell RNA, HSTR:Human Spatial Transcriptome RNA); CancerType(01:AM, 02:BCC, 03:BW, 04:CM, 05:CSCC, 06:CSDM, 07:LSCC, 08:LUAD, 09:MM, 10:nCSDM, 11:LSCC, 12:PC, 13:PSCC, XX:multiple cancer, 00:LUNG); SampleType(00:Mixed sampling, 01:Primary Solid Tumor, 02:Lymph Node Metastatic, 03:Solid Tissue Normal, 04:Normal Tissue, 05:Normal Congenital Nevi)) |
Attributes | *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA007441 in the GSA-Human system. |
Release date | 2024-05-24 |
BioProject Accession | PRJCA018695 |
Submitter | Mingzhu Yin (yinmingzhu2008@126.com) |
Organization | Chongqing University Three Gorges Hospital |
Submission date | 2024-05-25 |
Resource name | Description |
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GSA-Human (1) | - |
HRA007441 (Controlled Access) | Tumor growth cannot flourish without the oxygen and nutrients supplied by the blood, making angiogenesis induction one of the most critical cancer hallmarks. In this study, we generated a pan-tumor vasculature atlas by integrating in-house and public single-cell datasets. At the single-cell resolution, we dissected ~200,000 vascular cells, including vascular endothelial cells (ECs), lymphatic ECs (LECs), and mural cells (MCs). Our findings contributed to understanding the tumor angiogenesis processes, LEC lineages, MC phenotypes, and intercellular interactions associated with the tumor vascular microenvironment (TVM). Our comprehensive TVM compilations complemented a missing piece of jigsaw puzzle for the single-cell pan-tumor atlas and provided a reference perspective on tumor vascular normalization and anti-angiogenic therapy. |