| 项目编号 | PRJCA021346 | |||||||||||||||
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| 项目标题 | Single cell atlas of Crohn's disease reveals the pivotal role of FAP+ fibroblasts in the microenvironment of intestinal fibrosis | |||||||||||||||
| 涉及领域 | Medical | |||||||||||||||
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads Single cell sequencing |
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| 物种名称 |
Mus musculus
Homo sapiens |
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| 描述信息 | Intestinal fibrosis, a common complication of Crohn's disease,is characterized by excessive extracellular matrix (ECM) deposition which induces intestinal strictures. This study aims to identify the main producer of the pathogenic ECM and explore potential therapeutic targets. We obtained the normal and fibrotic intestinal tissues from Crohn's disease patients with intestinal obstruction. Single-cell RNA sequencing (scRNA-seq) was operated on the intestinal specimens. | |||||||||||||||
| 样品范围 | Single cell | |||||||||||||||
| 发布日期 | 2025-01-03 | |||||||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Duowu Zou (zdwrjxh66@sjtu.edu.cn) | |||||||||||||||
| 提交单位 | Ruijin Hospital, Shanghai jiaotong University School of Medicine | |||||||||||||||
| 提交日期 | 2023-11-16 |