| 项目编号 | PRJCA021482 | ||||||||||
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| 项目标题 | Molecular mutation spectrums and subtyping in Primary Central Nervous System Lymphoma | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 | Exome | ||||||||||
| 物种名称 | Homo sapiens | ||||||||||
| 描述信息 | The investigation of molecular mutation spectrums and subtyping in Primary Central Nervous System Lymphoma (PCNSL) within the Chinese population encounters numerous challenges. Firstly, due to PCNSL's low incidence rate and the inherent difficulty in obtaining samples, most current studies are limited by small sample sizes and are predominantly single-centered. This significantly restricts our ability to comprehensively understand the genetic mutation characteristics of PCNSL in the Chinese demographic. Additionally, molecular subtyping models proposed by international teams may not fully apply to Chinese PCNSL patients, given the variations in ethnicity, geographical factors, and other biological aspects. Addressing these key issues, this project aims to undertake the following research initiatives: Execute a multicenter, large-scale exome sequencing study tailored to the Chinese PCNSL population. This effort aims to refine the mutation profile for Chinese PCNSL patients, integrating cross-analysis with international research findings to highlight unique molecular mutation features specific to this group. Employing advanced bioinformatics algorithms in conjunction with the multicenter, large-scale exome sequencing data, this study seeks to establish a molecular classification scheme tailored for Chinese PCNSL. This approach is anticipated to uncover novel therapeutic targets and biomarkers, significantly contributing to the field of personalized medicine in PCNSL treatment. | ||||||||||
| 样品范围 | Monoisolate | ||||||||||
| 发布日期 | 2023-11-22 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Wei Hua (hs_huawei@126.com) | ||||||||||
| 提交单位 | Huashan Hospital Fudan University | ||||||||||
| 提交日期 | 2023-11-22 |
| 资源名称 | 描述 |
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| BioSample (199) show | - |