| HRA006122
(Controlled Access)
|
The WES data of the 140 patients of PCNSL. The investigation of molecular mutation spectrums and subtyping in Primary Central Nervous System Lymphoma (PCNSL) within the Chinese population encounters numerous challenges. Firstly, due to PCNSL's low incidence rate and the inherent difficulty in obtaining samples, most current studies are limited by small sample sizes and are predominantly single-centered. This significantly restricts our ability to comprehensively understand the genetic mutation characteristics of PCNSL in the Chinese demographic. Additionally, molecular subtyping models proposed by international teams may not fully apply to Chinese PCNSL patients, given the variations in ethnicity, geographical factors, and other biological aspects. Addressing these key issues, this project aims to undertake the following research initiatives: Execute a multicenter, large-scale exome sequencing study tailored to the Chinese PCNSL population. |
