| 项目编号 |
PRJCA022115 |
| 项目标题 |
Divergent originations of parental DNA hydroxymethylation in human preimplantation embryos |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Epigenetic dysregulation is associated with human infertility and abnormal embryonic development. One important epigenetic modification is DNA 5-hydroxymethylcytosine (5hmC), the conversion of methylcytosine (5mC) to 5hmC by TET enzymes. However, the role of this modification in early human embryos remains largely unknown. Here, we present a single-base-resolution map of 5hmC during human preimplantation development. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-06-24 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39080410
|
Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression
|
Nature Cell Biology
|
10.1038/s41556-024-01475-y
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82325022
|
|
| National Natural Science Foundation of China (NSFC)
|
|
U20A20350
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81971455
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82101802
|
|
| National Natural Science Foundation of China (NSFC)
|
|
2021YFC2700901
|
|
| Chinese Academy of Sciences (CAS)
|
|
YSBR-012
|
|
| Chinese Academy of Sciences (CAS)
|
|
XJ2020025
|
|
|
|
| 提交者 |
Fan
Guo (guofan@ioz.ac.cn)
|
| 提交单位 |
Institute of Zoology, Chinese Academy of Sciences |
| 提交日期 |
2023-12-16 |
