| Accession |
PRJCA022115 |
| Title |
Divergent originations of parental DNA hydroxymethylation in human preimplantation embryos |
| Relevance |
Medical |
| Data types |
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
Epigenetic dysregulation is associated with human infertility and abnormal embryonic development. One important epigenetic modification is DNA 5-hydroxymethylcytosine (5hmC), the conversion of methylcytosine (5mC) to 5hmC by TET enzymes. However, the role of this modification in early human embryos remains largely unknown. Here, we present a single-base-resolution map of 5hmC during human preimplantation development. |
| Sample scope |
Monoisolate |
| Release date |
2024-06-24 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 39080410
|
Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression
|
Nature Cell Biology
|
10.1038/s41556-024-01475-y
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82325022
|
|
| National Natural Science Foundation of China (NSFC)
|
|
U20A20350
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81971455
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82101802
|
|
| National Natural Science Foundation of China (NSFC)
|
|
2021YFC2700901
|
|
| Chinese Academy of Sciences (CAS)
|
|
YSBR-012
|
|
| Chinese Academy of Sciences (CAS)
|
|
XJ2020025
|
|
|
|
| Submitter |
Fan
Guo (guofan@ioz.ac.cn)
|
| Organization |
Institute of Zoology, Chinese Academy of Sciences |
| Submission date |
2023-12-16 |
