Accession

PRJCA023187

Title

Distinct intrinsic molecular profiles drive multifaceted cellular instincts in metastatic seeds of primary colorectal cancer

Relevance

Medical

Data types

Transcriptome or Gene expression
Raw sequence reads

Organisms

Homo sapiens

Description

Metastasis of primary tumors remains a challenge for early diagnosis and prevention. The cellular properties and molecular drivers of metastatically competent clones within primary tumors remain unclear. Here, we generated 10-16 single-cell-derived lines from each of three colorectal cancer (CRC) tumors to identify and characterize metastatic seeds.

Sample scope

Monoisolate

Release date

2024-01-25

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		2021YFA1100103
Beijing Natural Science Foundation		Z190016
National Natural Science Foundation of China (NSFC)		32070796
Institute for Intelligent Healthcare, Tsinghua University; CAMS Innovation Fund for Medical Sciences		2022-I2M-1-009
Institute for Intelligent Healthcare, Tsinghua University; CAMS Innovation Fund for Medical Sciences		021-I2M-1-067
Grant from Tsinghua Precision Medicine Foundation		10001020121

Submitter

Xia Wang (xiawang@mail.tsinghua.edu.cn)

Organization

Tsinghua University

Submission date

2024-01-25

Project Data

Resource name	Description
BioSample (48) show	-
SAMC3328412	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328411	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328410	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328409	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328408	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328407	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328406	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328405	sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture
SAMC3328404	Single-cell derived PDCC(SC-PDCC)
SAMC3328403	Single-cell derived PDCC(SC-PDCC)
SAMC3328402	Single-cell derived PDCC(SC-PDCC)
SAMC3328401	Single-cell derived PDCC(SC-PDCC)
SAMC3328400	Single-cell derived PDCC(SC-PDCC)
SAMC3328399	Single-cell derived PDCC(SC-PDCC)
SAMC3328398	Single-cell derived PDCC(SC-PDCC)
SAMC3328397	Single-cell derived PDCC(SC-PDCC)
SAMC3328396	Single-cell derived PDCC(SC-PDCC)
SAMC3328395	Single-cell derived PDCC(SC-PDCC)
SAMC3328394	Single-cell derived PDCC(SC-PDCC)
SAMC3328393	Single-cell derived PDCC(SC-PDCC)
SAMC3328392	Single-cell derived PDCC(SC-PDCC)
SAMC3328391	Single-cell derived PDCC(SC-PDCC)
SAMC3328390	Single-cell derived PDCC(SC-PDCC)
SAMC3328389	Single-cell derived PDCC(SC-PDCC)
SAMC3328388	Single-cell derived PDCC(SC-PDCC)
SAMC3328387	Single-cell derived PDCC(SC-PDCC)
SAMC3328386	Single-cell derived PDCC(SC-PDCC)
SAMC3328385	Single-cell derived PDCC(SC-PDCC)
SAMC3328384	Single-cell derived PDCC(SC-PDCC)
SAMC3328383	Single-cell derived PDCC(SC-PDCC)
SAMC3328382	Single-cell derived PDCC(SC-PDCC)
SAMC3328381	Single-cell derived PDCC(SC-PDCC)
SAMC3328380	Single-cell derived PDCC(SC-PDCC)
SAMC3328379	Single-cell derived PDCC(SC-PDCC)
SAMC3328378	Single-cell derived PDCC(SC-PDCC)
SAMC3328377	Single-cell derived PDCC(SC-PDCC)
SAMC3328376	Single-cell derived PDCC(SC-PDCC)
SAMC3328375	Single-cell derived PDCC(SC-PDCC)
SAMC3328374	Single-cell derived PDCC(SC-PDCC)
SAMC3328373	Single-cell derived PDCC(SC-PDCC)
SAMC3328372	Single-cell derived PDCC(SC-PDCC)
SAMC3328371	Single-cell derived PDCC(SC-PDCC)
SAMC3328370	Single-cell derived PDCC(SC-PDCC)
SAMC3328369	Single-cell derived PDCC(SC-PDCC)
SAMC3328368	Single-cell derived PDCC(SC-PDCC)
SAMC3328367	Single-cell derived PDCC(SC-PDCC)
SAMC3328366	Single-cell derived PDCC(SC-PDCC)
SAMC3328365	Single-cell derived PDCC(SC-PDCC)