| Accession | SAMC3328406 |
|---|---|
| Accession in Other Database | GSA-Human: HRS1039366 |
| Sample name | SALI02 |
| Title | sample derived from 3D Air-liquid interface organoids (ALI-PDO) culture |
| Sample type | Human sample |
| Organism | Homo sapiens |
| Description | 3D Air-liquid interface organoids (ALI-PDO) culture for D021; well differentiation (WD) |
| Attributes | *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA006587 in the GSA-Human system. |
| Release date | 2024-01-26 |
| BioProject Accession | PRJCA023187 |
| Submitter | Xia Wang (xiawang@mail.tsinghua.edu.cn) |
| Organization | Tsinghua University |
| Submission date | 2024-01-27 |
| Resource name | Description |
|---|---|
| GSA-Human (1) | - |
| HRA006587 (Controlled Access) | Metastasis of primary tumors remains a challenge for early diagnosis and prevention. The cellular properties and molecular drivers of metastatically competent clones within primary tumors remain unclear. Here, we generated 10-16 single-cell-derived lines from each of three colorectal cancer (CRC) tumors to identify and characterize metastatic seeds. We found that intrinsic factors conferred clones with distinct metastatic potential and cellular communication capabilities, determining organ-specific metastasis. Poorly differentiated or highly metastatic clones, rather than drug-resistant clones, exhibited poor clinical prognostic impact. |