| 项目编号 |
PRJCA024399 |
| 项目标题 |
Matrix stiffness-tuned exosomal miRNAs promote lung metastasis in HCC |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Existing clinical studies have indicated that increased matrix stiffness is positively correlated with an unfavorable prognosis of HCC, and liver stiffness has been taken as a biomarker in clinics to predict HCC progress and its outcome. This study aims to explore whether increased matrix stiffness tuned HCC cell-released exosomal miRNAs trigger HCC metastasis. Exosomes were first isolated and purified from CM of MHCC97H cells grown on low (6 kPa) and high-stiffness (16 kPa) substrates. Small RNAs in exosomes were further subjected to sequencing via the Illumina NovaSeq 6000 platform. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-12-21 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82272959
|
|
|
|
| 提交者 |
Jiefeng
Cui (cui.jiefeng@zs-hospital.sh.cn)
|
| 提交单位 |
Zhongshan Hospital, Fudan University |
| 提交日期 |
2024-03-18 |
