| 项目编号 |
PRJCA028778 |
| 项目标题 |
Single-Cell RNA Sequencing Elucidates Cellular Plasticity in Esophageal Small Cell Carcinoma Following Chemotherapy Treatment |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Small cell carcinoma of the esophagus (SCCE) is a rare and aggressive malignancy that poses significant clinical challenges. This study employs single-cell RNA sequencing (scRNA-seq) to investigate SCCE samples from a single patient before and after chemotherapy. The analysis reveals notable cellular plasticity and changes in the tumor microenvironment's cellular composition, including increased tumor cell diversity and decreased populations of T cells, B cells, and myeloid-like cells. Pre-treatment samples predominantly show carcinoma cells in a middle transitional state, while post-treatment samples exhibit expanded populations of cells in terminal and universally altered states. Dynamic interactions between tumor and immune cells, particularly through key signaling pathways such as TIGIT-PVR and MDK-SDC4, are highlighted. This research offers new insights into the adaptive mechanisms of SCCE following chemotherapy and identifies potential therapeutic targets to enhance treatment efficacy. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-08-02 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39850495
|
Single-cell RNA sequencing elucidates cellular plasticity in esophageal small cell carcinoma following chemotherapy treatment
|
Frontiers in Genetics
|
10.3389/fgene.2024.1477705
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| the High-level Hospital Construction Project
|
|
DFJHBF202102
|
|
|
|
| 提交者 |
Zhao
Wei (zhaowei23@mail.sysu.edu.cn)
|
| 提交单位 |
Sun Yat-sen University |
| 提交日期 |
2024-08-02 |
