样本编号	SAMC4065657
外部数据库编号	GSA-Human: HRS1336269
样品名称	SCCE_S1
样本标题	scRNA-seq data of SCCE patient before treatment
样品类型	Human sample
物种名称	Homo sapiens
描述信息	scRNA-seq data of SCCE patient before treatment
样本属性	*该样本包含更多受控访问信息，请通过GSA-Human系统申请项目HRA008234数据获取。
发布日期	2024-12-21
项目编号	PRJCA028778
提交者	Zhao Wei (zhaowei23@mail.sysu.edu.cn)
提交单位	Sun Yat-sen University
提交日期	2024-08-10

样本包含数据信息

资源名称	描述
GSA-Human (1)	-
HRA008234 (Controlled Access)	Small cell carcinoma of the esophagus (SCCE) is a rare, aggressive malignancy presenting significant clinical challenges. Chemotherapy manages early-stage symptoms but has limited long-term effectiveness, with mechanisms poorly understood. We used single-cell RNA sequencing (scRNA-seq) to analyze SCCE samples from a patient before and after chemotherapy. Our findings showed notable cellular plasticity and changes in the tumor microenvironment. Tumor cell diversity increased, while T cells, B cells, and myeloid-like cells decreased. Pre-treatment samples featured carcinoma cells in a middle transitional state, while post-treatment samples showed cells in terminal, initial-to-terminal (IniTerm), and universally altered states. Further analysis revealed dynamic tumor-immune cell interactions and changes in key signaling pathways like TIGIT-PVR and MDK-SDC4. This study sheds light on cell plasticity dynamics in SCCE post-chemotherapy, offering new insights and potential therapeutic targets for improved treatment.

资源名称

描述

GSA-Human (1)

HRA008234 (Controlled Access)

Small cell carcinoma of the esophagus (SCCE) is a rare, aggressive malignancy presenting significant clinical challenges. Chemotherapy manages early-stage symptoms but has limited long-term effectiveness, with mechanisms poorly understood. We used single-cell RNA sequencing (scRNA-seq) to analyze SCCE samples from a patient before and after chemotherapy. Our findings showed notable cellular plasticity and changes in the tumor microenvironment. Tumor cell diversity increased, while T cells, B cells, and myeloid-like cells decreased. Pre-treatment samples featured carcinoma cells in a middle transitional state, while post-treatment samples showed cells in terminal, initial-to-terminal (IniTerm), and universally altered states. Further analysis revealed dynamic tumor-immune cell interactions and changes in key signaling pathways like TIGIT-PVR and MDK-SDC4. This study sheds light on cell plasticity dynamics in SCCE post-chemotherapy, offering new insights and potential therapeutic targets for improved treatment.