| 项目编号 |
PRJCA036189 |
| 项目标题 |
Single cell RNA-seq indicated the effect of putrescine on the CXCR6+CD8+T cells in DSS-induced colitis |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Based on previous experimental findings, we observed the anti-tumor activity of CXCR6+CD8+ T cells. Moreover, putrescine, a substance that can be produced by both host sources and the gut microbiota, plays a significant role in colorectal cancer (CRC). To clarify the characteristics of CXCR6+CD8+ T cells in DSS-induced colitis and their association with intestinal putrescine, we established a model and randomly obtained three colons from each group to extract lamina propria mononuclear cells (LPMC) for single-cell sequencing analysis. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-04-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41700134
|
Multiomics analysis of polyamine metabolism in colorectal cancer, highlighting the key role of extracellular putrescine in impairing CXCR6 + CD8 + T cell anti-tumor activity
|
PeerJ
|
10.7717/peerj.20663
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
NA
|
|
|
|
| 提交者 |
Bin
Wang (bwang_bzmc@bzmc.edu.cn)
|
| 提交单位 |
Binzhou Medical University |
| 提交日期 |
2025-02-16 |
