项目编号

PRJCA039760

项目标题

Progressive and Concordant Alterations in Transcriptional and Gut Microbiota Across Aortic Valve Calcification Severity

涉及领域

Medical

数据类型

Metagenome
Transcriptome or Gene expression

物种名称

Homo sapiens
human gut metagenome

描述信息

Aortic valve calcification (CAVD) is a prevalent disorder that leads to significant morbidity and mortality. The gut microbiota is thought to influence CAVD, but its characteristics across different levels of calcification are not well understood. This study investigated the transcriptional profiles of calcified aortic valve tissues from 31 patients with varying calcification levels and their corresponding gut microbiota characteristics. Our findings revealed subtle yet widespread transcriptional changes in mild CAVD (m-CAVD), indicating a dose-dependent relationship between calcification severity and gene expression. Notably, the gut microbiota in m-CAVD patients reflected a transitional state between healthy and severe profiles, suggesting its potential involvement in disease progression. Functional analysis also revealed specific bacterial taxa linked to calcification, highlighting the complex interactions between gut microbiota and the calcification process. These results enhanced our understanding of CAVD's pathophysiology and suggest that gut microbiota modulation, particularly in the early stages of the disease, could offer a new therapeutic strategy.

样品范围

Monoisolate

发布日期

2025-11-10

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
No funding support

提交者

Xiaobing Wang (gale820907@163.com)

提交单位

Second Affiliated Hospital of Naval Medical University

提交日期

2025-05-06

项目包含数据信息

资源名称	描述
BioSample (70) show	-
SAMC6575601	transcriptomic profiles of aortic valve tissues
SAMC6575600	transcriptomic profiles of aortic valve tissues
SAMC6575599	transcriptomic profiles of aortic valve tissues
SAMC6575598	transcriptomic profiles of aortic valve tissues
SAMC6575597	transcriptomic profiles of aortic valve tissues
SAMC6575596	transcriptomic profiles of aortic valve tissues
SAMC6575595	transcriptomic profiles of aortic valve tissues
SAMC6575594	transcriptomic profiles of aortic valve tissues
SAMC6575593	transcriptomic profiles of aortic valve tissues
SAMC6575592	transcriptomic profiles of aortic valve tissues
SAMC6575591	transcriptomic profiles of aortic valve tissues
SAMC6575590	transcriptomic profiles of aortic valve tissues
SAMC6575589	transcriptomic profiles of aortic valve tissues
SAMC6575588	transcriptomic profiles of aortic valve tissues
SAMC6575587	transcriptomic profiles of aortic valve tissues
SAMC6575586	transcriptomic profiles of aortic valve tissues
SAMC6575585	transcriptomic profiles of aortic valve tissues
SAMC6575584	transcriptomic profiles of aortic valve tissues
SAMC6575583	transcriptomic profiles of aortic valve tissues
SAMC6575582	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
	transcriptomic profiles of aortic valve tissues
SAMC6098088	Gut microbiome of human fecal S_CAVD_6
SAMC6098087	Gut microbiome of human fecal S_CAVD_5
SAMC6098086	Gut microbiome of human fecal S_CAVD_4
SAMC6098085	Gut microbiome of human fecal S_CAVD_3
SAMC6098084	Gut microbiome of human fecal S_CAVD_2
SAMC6098083	Gut microbiome of human fecal S_CAVD_1
SAMC6098082	Gut microbiome of human fecal M_CAVD_16
SAMC6098081	Gut microbiome of human fecal M_CAVD_15
SAMC6098080	Gut microbiome of human fecal M_CAVD_14
SAMC6098079	Gut microbiome of human fecal M_CAVD_13
SAMC6098078	Gut microbiome of human fecal M_CAVD_12
SAMC6098077	Gut microbiome of human fecal M_CAVD_11
SAMC6098076	Gut microbiome of human fecal M_CAVD_10
SAMC6098075	Gut microbiome of human fecal M_CAVD_9
SAMC6098074	Gut microbiome of human fecal M_CAVD_8
SAMC6098073	Gut microbiome of human fecal M_CAVD_7
SAMC6098072	Gut microbiome of human fecal M_CAVD_6
SAMC6098071	Gut microbiome of human fecal M_CAVD_5
SAMC6098070	Gut microbiome of human fecal M_CAVD_4
SAMC6098069	Gut microbiome of human fecal M_CAVD_3
SAMC6098068	Gut microbiome of human fecal M_CAVD_2
SAMC6098067	Gut microbiome of human fecal M_CAVD_1
SAMC6098066	Gut microbiome of human fecal non_CAVD_8
SAMC6098065	Gut microbiome of human fecal non_CAVD_7
SAMC6098064	Gut microbiome of human fecal non_CAVD_6
SAMC6098063	Gut microbiome of human fecal non_CAVD_5
SAMC6098062	Gut microbiome of human fecal non_CAVD_4
SAMC6098061	Gut microbiome of human fecal non_CAVD_3
SAMC6098060	Gut microbiome of human fecal non_CAVD_2
SAMC6098059	Gut microbiome of human fecal non_CAVD_1
GSA (1)	-
CRA033462	Progressive and Concordant Alterations in Transcriptional and Gut Microbiota Across Aortic Valve Calcification Severity