| HRA014730
(Controlled Access)
|
This study explores the pathogenesis of calcific aortic valve disease (CAVD) by integrating RNA-seq data from human aortic valve tissues with 16S rRNA sequencing data from matched stool samples. We included patients with non-calcified, mildly calcified, and severely calcified aortic valves. Our analysis reveals stage-dependent transcriptional changes in the valve and corresponding shifts in gut microbiota composition, suggesting a potential gut-heart axis in CAVD progression. This resource enables further investigation into the molecular and microbial drivers of aortic valve calcification. |
