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项目编号 PRJCA040531
项目标题 RNA-seq of NIID cell and mouse models before and after gene therapy
涉及领域 Medical
数据类型 Transcriptome or Gene expression
物种名称 Homo sapiens
描述信息 Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by GGC repeat expansion in the NOTCH2NLC gene. Using CRISPR/Cas9 technology, we performed gene editing targeting these GGC repeats in both human neural progenitor cells (NPCs) and NIID mouse models. Subsequent RNA-seq analysis compared transcriptional profiles between edited and unedited models, as well as normal controls.
样品范围 Multispecies
发布日期 2025-12-01
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 82394421
National Natural Science Foundation of China (NSFC) 82394420
National Natural Science Foundation of China (NSFC) 82394422
National Natural Science Foundation of China (NSFC) 82371874
National Natural Science Foundation of China (NSFC) 82271902
National Natural Science Foundation of China (NSFC) U24A6013
National Natural Science Foundation of China (NSFC) 32071037
National Natural Science Foundation of China (NSFC) 82171843
National Natural Science Foundation of China (NSFC) 82101946
National Natural Science Foundation of China (NSFC) 82171256
Ministry of Science and Technology of the People's Republic of China (MOST) 2021YFA0805200
Natural Science Foundation of Hunan Province 2023JJ10097
Natural Science Foundation of Hunan Province 2025JJ20079
Natural Science Foundation of Hunan Province 2022JJ40832
提交者 Yongcheng Pan (panyongcheng@csu.edu.cn)
提交单位 Xiangya Hospital Central South University
提交日期 2025-05-22

项目包含数据信息

资源名称 描述
BioSample (12)  show -