Accession SAMC1343246
Accession in Other Database GSA-Human: HRS033379
Sample name Normal_2_2_10_5
Title Single-cell multi-omics sequencing of human adult testicular sample of Normal_2
Sample type Human sample
Organism Homo sapiens
Description Single-cell multi-omics sequencing of human adult testicular sample of Normal_2
Attributes *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA000148 in the GSA-Human system.
Release date 2022-04-15
BioProject Accession PRJCA002540
Submitter Lin  Li  (smull22@smu.edu.cn)
Organization Southern Medical University
Submission date 2023-06-17

Sample Data

Resource name Description
GSA-Human (1) -
HRA000148  (Controlled Access) Stepwise and sequential cell fate transition accomplished by global transcriptional changes occurs across human spermatogenesis, but the epigenome roadmap and regulatory networks underlying this process have not been established. Here, we explore a single-cell multi-omics landscape of human adult testicular cells using the single-cell chromatin overall omic-scale landscape sequencing (scCOOL-seq) technique, deriving an unbiased multi-omics reference map of human adult spermatogenesis. The initial commitment to meiosis coincides with a novel dramatic DNA demethylation process in non-coding regions that highly overlapped with crossover and double strand break (DSB) hotspots. Chromatin accessibility mainly accounts for the global expression dynamics in human spermatogenesis. Further studies identify the cis- regulatory elements of several key regulators such as STRA8, ID3, HMGA1 and TEX29 in human spermatogenesis.
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