| HRA000021
(Controlled Access)
|
In this project, we performed deep WGS in microneedle-punctured formalin fixed paraffin embedded tumor tissues and matched adjacent noncancerous specimens on a large set of ESCC patients with clinical follow up data. Herein, we classify ESCC into three main subtypes based on clinically relevant genomic alterations and implicate the association of these subtypes with outcomes of patients. Our genomic study uncovers an extensive landscape of driver genetic alterations across coding and noncoding regions, and defines their potential molecular pathology in ESCC. |
