HRA000912
(Controlled Access)
|
The aim of the study was to validate the diagnostic role of circulating tumor DNA (ctDNA) in genetics aberration on basis of next-generation sequencing (NGS) in pediatric acute myeloid leukemia (AML).Bone marrow (BM) and peripheral blood (PB) were collected from 20 AML children at the time of initial diagnosis, and ctDNA sample was isolated from PB. Detection of mutation was performed on ctDNA, BM and peripheral blood mononuclear cell (PBMC) by NGS based on a 185-gene panel. |