样本编号

SAMC1833967

外部数据库编号

样品名称

FLAG-CTCF_rep1.RNA-Seq

样本标题

FLAG-CTCF_rep1.RNA-Seq

样品类型

Human sample

物种名称

Homo sapiens

描述信息

HeLa-S3 cells were infected with lentivirus.After infection, puromycin was added to the medium to select the positively infected cells.

样本属性

分离株名称	not collected
年龄
实验材料提供者	Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
性别	female
组织器官	cervical adenocarcinoma cell line
疾病名称
细胞系
细胞亚型
细胞类型
收集/保存方法
发育阶段
疾病分期
血统性（民族）
健康状况
核型
表型
人口
种族（人种）
类型
处理方法
采样日期	2017-08-26

用户自定义属性

发布日期

2021-06-23

项目编号

PRJCA005419

提交者

Hongjie Yao (yao_hongjie@gzlab.ac.cn)

提交单位

Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences

提交日期

2023-06-18

样本包含数据信息

资源名称	描述
GSA-Human (1)	-
HRA000960 (Open Access)	Here, we explore the functions of an alternatively spliced human CTCF isoform (CTCF-s). Functionally, we find that CTCF-s competes with the genome binding of canonical CTCF and binds a similar DNA sequence. CTCF-s binding disrupts CTCF/cohesin binding, alters CTCF-mediated chromatin looping and promotes the activation of IFI6 that leads to apoptosis. This effect is caused by an abnormal long-range interaction at the IFI6 enhancer and promoter.

资源名称

描述

GSA-Human (1)

HRA000960 (Open Access)

Here, we explore the functions of an alternatively spliced human CTCF isoform (CTCF-s). Functionally, we find that CTCF-s competes with the genome binding of canonical CTCF and binds a similar DNA sequence. CTCF-s binding disrupts CTCF/cohesin binding, alters CTCF-mediated chromatin looping and promotes the activation of IFI6 that leads to apoptosis. This effect is caused by an abnormal long-range interaction at the IFI6 enhancer and promoter.