样本编号 SAMC1889169
外部数据库编号 GSA-Human: HRS276024
样品名称 SCLC_P02_T1
样本标题 SCLC_P02_T1_1
样品类型 Human sample
物种名称 Homo sapiens
描述信息 NGS of small cell lung cancer
样本属性 *该样本包含更多受控访问信息,请通过GSA-Human系统申请项目HRA001232数据获取。
发布日期 2022-11-23
项目编号 PRJCA006026
提交者 Shu  Zhang  (tangfuchou@pku.edu.cn)
提交单位 BIOPIC
提交日期 2023-06-18

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA001232  (Controlled Access) Small-cell lung cancer (SCLC) is the most aggressive and lethal subtype of lung cancer for which better understandings of its biology are urgently needed. Single-cell sequencing technologies provide an opportunity to profile individual cells within the tumor microenvironment (TME) and investigate their roles in tumorigenesis processes. Here, we performed high-precision single-cell transcriptomic analysis of ~5,000 individual cells from primary tumors and matched adjacent normal lung tissues (NATs) from 11 SCLC patients, including one patient with primary and relapsed tumors. By comparing to NATs, our study revealed an immune suppressive landscape of human SCLC. Malignant cells of SCLC tumors exhibited the diversity of states mainly regarding to the cell cycle, immune and hypoxia properties. Our data also revealed intra-tumor heterogeneity of key transcriptomic factors of SCLC at single cell resolution, and uncovered related genes expression patterns and functions.