| Accession | SAMC1892742 |
|---|---|
| Accession in Other Database | GSA-Human: HRS276171 |
| Sample name | P4-T2 |
| Title | multiple primary lung adenocarcinomas |
| Sample type | Human sample |
| Organism | Homo sapiens |
| Description | Actionable gene mutation analysis of surgery tissue samples was determined by capture single molecule amplification and resequencing technology (capSMART) for a targeted NGS panel assay of 10 NSCLC-related driver genes. |
| Attributes | *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA001237 in the GSA-Human system. |
| Release date | 2021-08-31 |
| BioProject Accession | PRJCA006357 |
| Submitter | pingping song (spp128@126.com) |
| Organization | Tumor Hospital affiliated to Shandong First Medical University |
| Submission date | 2023-06-18 |
| Resource name | Description |
|---|---|
| GSA-Human (1) | - |
| HRA001237 (Controlled Access) | Multiple primary lung cancers (MPLCs) are an increasingly well-known clinical phenomenon, but there is a lack of high-level evidence for their optimal clinical diagnosis and therapeutic approaches. Thus, we analysed genetic variation to determine the intertumoural heterogeneity and branch evolution of synchronous multiple primary lung adenocarcinomas. We performed multiplex mutational sequencing on 93 synchronous multiple primary lung adenocarcinoma lesions from 42 patients who underwent surgical resection. Remarkable intertumoural heterogeneity and frequent branch mutations were found in synchronous multiple primary lung adenocarcinomas. |