Accession

PRJCA006357

Title

Intertumoural Heterogeneity and Branch Evolution of Synchronous Multiple Primary Lung Adenocarcinomas by Next-Generation Sequencing Analysis

Relevance

Medical

Data types

Raw sequence reads
Genome sequencing

Organisms

Homo sapiens

Description

Multiple primary lung cancers (MPLCs) are an increasingly well-known clinical phenomenon, but there is a lack of high-level evidence for their optimal clinical diagnosis and therapeutic approaches. Thus, we analysed genetic variation to determine the intertumoural heterogeneity and branch evolution of synchronous multiple primary lung adenocarcinomas. We performed multiplex mutational sequencing on 93 synchronous multiple primary lung adenocarcinoma lesions from 42 patients who underwent surgical resection. Remarkable intertumoural heterogeneity and frequent branch mutations were found in synchronous multiple primary lung adenocarcinomas.

Sample scope

Multiisolate

Release date

2021-08-30

Grants

Agency	program	Grant ID	Grant title
Development Center for Medical Science Technology National Health Commission of the People		WA2021RW02

Submitter

pingping song (spp128@126.com)

Organization

Tumor Hospital affiliated to Shandong First Medical University

Submission date

2021-08-30

Project Data

Resource name	Description
BioSample (93) show	-
SAMC1893092	multiple primary lung adenocarcinomas
SAMC1893088	multiple primary lung adenocarcinomas
SAMC1893081	multiple primary lung adenocarcinomas
SAMC1893077	multiple primary lung adenocarcinomas
SAMC1893072	multiple primary lung adenocarcinomas
SAMC1893068	multiple primary lung adenocarcinomas
SAMC1893058	multiple primary lung adenocarcinomas
SAMC1893054	multiple primary lung adenocarcinomas
SAMC1893050	multiple primary lung adenocarcinomas
SAMC1893046	multiple primary lung adenocarcinomas
SAMC1893042	multiple primary lung adenocarcinomas
SAMC1893038	multiple primary lung adenocarcinomas
SAMC1893034	multiple primary lung adenocarcinomas
SAMC1893030	multiple primary lung adenocarcinomas
SAMC1893027	multiple primary lung adenocarcinomas
SAMC1893023	multiple primary lung adenocarcinomas
SAMC1893018	multiple primary lung adenocarcinomas
SAMC1893014	multiple primary lung adenocarcinomas
SAMC1893009	multiple primary lung adenocarcinomas
SAMC1893004	multiple primary lung adenocarcinomas
SAMC1893001	multiple primary lung adenocarcinomas
SAMC1892997	multiple primary lung adenocarcinomas
SAMC1892993	multiple primary lung adenocarcinomas
SAMC1892989	multiple primary lung adenocarcinomas
SAMC1892985	multiple primary lung adenocarcinomas
SAMC1892981	multiple primary lung adenocarcinomas
SAMC1892977	multiple primary lung adenocarcinomas
SAMC1892974	multiple primary lung adenocarcinomas
SAMC1892969	multiple primary lung adenocarcinomas
SAMC1892965	multiple primary lung adenocarcinomas
SAMC1892962	multiple primary lung adenocarcinomas
SAMC1892957	multiple primary lung adenocarcinomas
SAMC1892952	multiple primary lung adenocarcinomas
SAMC1892945	multiple primary lung adenocarcinomas
SAMC1892940	multiple primary lung adenocarcinomas
SAMC1892935	multiple primary lung adenocarcinomas
SAMC1892931	multiple primary lung adenocarcinomas
SAMC1892927	multiple primary lung adenocarcinomas
SAMC1892922	multiple primary lung adenocarcinomas
SAMC1892918	multiple primary lung adenocarcinomas
SAMC1892910	multiple primary lung adenocarcinomas
SAMC1892906	multiple primary lung adenocarcinomas
SAMC1892902	multiple primary lung adenocarcinomas
SAMC1892898	multiple primary lung adenocarcinomas
SAMC1892895	multiple primary lung adenocarcinomas
SAMC1892892	multiple primary lung adenocarcinomas
SAMC1892888	multiple primary lung adenocarcinomas
SAMC1892884	multiple primary lung adenocarcinomas
SAMC1892880	multiple primary lung adenocarcinomas
SAMC1892876	multiple primary lung adenocarcinomas
SAMC1892873	multiple primary lung adenocarcinomas
SAMC1892870	multiple primary lung adenocarcinomas
SAMC1892867	multiple primary lung adenocarcinomas
SAMC1892862	multiple primary lung adenocarcinomas
SAMC1892858	multiple primary lung adenocarcinomas
SAMC1892854	multiple primary lung adenocarcinomas
SAMC1892851	multiple primary lung adenocarcinomas
SAMC1892847	multiple primary lung adenocarcinomas
SAMC1892844	multiple primary lung adenocarcinomas
SAMC1892840	multiple primary lung adenocarcinomas
SAMC1892837	multiple primary lung adenocarcinomas
SAMC1892831	multiple primary lung adenocarcinomas
SAMC1892827	multiple primary lung adenocarcinomas
SAMC1892823	multiple primary lung adenocarcinomas
SAMC1892819	multiple primary lung adenocarcinomas
SAMC1892816	multiple primary lung adenocarcinomas
SAMC1892813	multiple primary lung adenocarcinomas
SAMC1892809	multiple primary lung adenocarcinomas
SAMC1892805	multiple primary lung adenocarcinomas
SAMC1892803	multiple primary lung adenocarcinomas
SAMC1892801	multiple primary lung adenocarcinomas
SAMC1892797	multiple primary lung adenocarcinomas
SAMC1892791	multiple primary lung adenocarcinomas
SAMC1892787	multiple primary lung adenocarcinomas
SAMC1892783	multiple primary lung adenocarcinomas
SAMC1892779	multiple primary lung adenocarcinomas
SAMC1892776	multiple primary lung adenocarcinomas
SAMC1892773	multiple primary lung adenocarcinomas
SAMC1892769	multiple primary lung adenocarcinomas
SAMC1892766	multiple primary lung adenocarcinomas
SAMC1892761	multiple primary lung adenocarcinomas
SAMC1892756	multiple primary lung adenocarcinomas
SAMC1892753	multiple primary lung adenocarcinomas
SAMC1892750	multiple primary lung adenocarcinomas
SAMC1892745	multiple primary lung adenocarcinomas
SAMC1892742	multiple primary lung adenocarcinomas
SAMC1892738	multiple primary lung adenocarcinomas
SAMC1892735	multiple primary lung adenocarcinomas
SAMC1892732	multiple primary lung adenocarcinomas
SAMC1892728	multiple primary lung adenocarcinomas
SAMC1892725	multiple primary lung adenocarcinomas
SAMC1892721	multiple primary lung adenocarcinomas
SAMC1892718	multiple primary lung adenocarcinomas