HRA002122
(Controlled Access)
|
This subject conducts clinical translational research on novel preimplantation genetic testing technology. The research is divided into two parts. In the first part, the construction and clinical translation of a preimplantation genetic testing platform based on single-molecule high-throughput sequencing (third-generation sequencing) technology were carried out. This technology will also effectively evaluate the chromosomal mosaicism embryos; and build libraries separately after biopsy samples are split to reduce the incidence of allelic dropout, provide a way to solve the two major problems faced by PGT, and open up new fields of PGT development.The second part studies the clinical translation research of non-invasive preimplantation genetic testing technology based on cell-free DNA detection in embryo culture medium. The development of non-invasive embryo chromosome screening technology will revolutionize the development of embryo developmental potential detection. |