样本编号 SAMC2276118
外部数据库编号 GSA-Human: HRS437095
样品名称 WT_3
样本标题 WT_3
样品类型 Human sample
物种名称 Homo sapiens
描述信息 bulk RNA seq
样本属性 *该样本包含更多受控访问信息,请通过GSA-Human系统申请项目HRA002894数据获取。
发布日期 2022-08-29
项目编号 PRJCA011156
提交者 xiaoqing  zhang  (xqzhang@tongji.edu.cn)
提交单位 Tongji University
提交日期 2023-06-18

样本包含数据信息

资源名称 描述
GSA-Human (1) -
HRA002894  (Controlled Access) Medial ganglionic eminence (MGE)-like cells yielded from human pluripotent stem cells (hPSCs) hold great potentials for cell therapies of related neurological disorders. In this study, we find that ablation of CTNNB1 in MGE cells led to precocious cell-cycle exit and advanced neuronal differentiation. Activation of WNT signaling through genetic or chemical approach was sufficient to maintain MGE cells in an expandable manner with authentic neuronal differentiation potencies through activation of endogenous NOTCH signaling. Our findings reveal that WNT/NOTCH signaling cascade is a key player in governing the maintenance versus terminal differentiation of MGE progenitors in humans.
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